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Sunday providing new users with another opportunity to use the latest FanDuel promo code, which offers new users $300 in bonus bets if their first wager of $5 or more wins. Week 6 of the 2025 NFL regular season has 12 games today. The San Francisco 49ers (4-1) and Tampa Bay Buccaneers (4-1) will meet at 4:25 p.m. ET. The Buccaneers are 3.5-point favorites, according to the latest NFL odds at FanDuel Sportsbook, up a half-point from the opening line, while the over/under for total points scored is 46.5.

SportsLine's model has the over cashing in 53% of simulations. The model's best bets also include the Cincinnati Bengals (+14.5) covering the spread in 55% of simulations against the Green Bay Packers in a game with an over-under of 44.5. Meanwhile, SportsLine's model is also backing the Lions (+2.5, 52) to cover the spread ion Sunday Night Football against the Chiefs at Arrowhead Stadium. Claim the latest FanDuel promo code here:

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The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 38-25 combined on money-line and over/under college football picks since the beginning of 2024. Anybody following its college football betting picks at sportsbooks and on betting sites could have seen strong returns.

Best Sunday NFL Week 6 picks

  • 49ers vs. Buccaneers: Over 47.5 total points 
  • Bengals (+14.5) vs. Packers 
  • Lions (+2.5) vs. Chiefs 

Combining the model's three picks into a three-leg parlay at FanDuel would result in a payout of +596 (risk $100 to win $596). Bet it at FanDuel here:

49ers vs. Buccaneers: Over 47.5 total points

The San Francisco 49ers ranked fifth in the NFL in total offense (375.8) and first in passing offense (290.6), with 21.2 points per game. The over has cleared in three of the last four games for San Francisco. As for the Buccaneers, they rank seventh in the NFL in scoring offense (27) and 11th in total offense (353.8). In addition, the over cashed in three straight games for Tampa Bay. SportsLine's model has these teams combining for 50 total points, as the over cashes in 53% of simulations. Bet it at FanDuel here:

Bengals (+14.5) vs. Packers 

The Bengals made the decision to trade for Joe Flacco after Jake Browning lost three straight matchups. Cincinnati's offense still features Ja'Marr Chase, who is 10th in the NFL in receiving yards (374) with three touchdowns. The Packers also enter this game 0-2 ATS as the away favorite. SportsLine's model has the Bengals covering the spread in 53% of simulations. Bet it at FanDuel now:

Lions (+2.5) vs. Chiefs

Detroit enters this contest on a four-game win streak. They are sixth in the NFL in total offense (365) and first in scoring offense (34.8). Meanwhile, the Lions are 3-0 ATS after a win. On the other side, Kansas City is 1-2 ATS as the favorite in 2025. SportsLine's model predicts that Detroit covers the spread in 52% of simulations. Bet it at FanDuel here:

Want more NFL picks?

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