MLS All-Star Game 2026: Odds, picks, betting preview, where to watch MLS vs. Liga MX on Wednesday

Most of the top players from MLS and Liga MX will square off again this year at the 2026 MLS All-Star Game, which is set for Wednesday night in Charlotte, N.C. This is the fifth time in six years the MLS All-Stars will take on the best players from Liga MX, Mexico's professional club league. The MLS All-Stars have won three of the previous four meetings, including a 3-1 victory last year. Some players who are coming off World Cup appearances will sit out, including Inter Miami superstar Lionel Messi, but many more, including USMNT captain Tim Ream, will be on the pitch Wednesday night.     

The 2026 MLS All-Star Game is scheduled to kick off at 8 p.m. ET at Bank of America Stadium and will stream on Apple TV. The MLS All-Stars are +110 money-line favorites in the MLS All-Star Game odds at bet365. Liga MX is a +175 underdog, while a 90-minute draw is +300. The Over/Under for total goals scored is set at 4.5. Here's a look at everything you need to know before making any soccer predictions on the 2026 MLS All-Star Game.

Bet on the MLS All-Star Game at bet365 and get $150 in bonus bets when you bet $10: 

MLS All-Star Game betting preview

It has been less than two weeks since the United States and Mexico co-hosted the 2026 World Cup, and now the top professional players from those two nations will face off in the the friendly showcase Wednesday in Charlotte, N.C. The MLS side took on the English Premier League's Arsenal in the annual exhibition in 2023, after the Americans took the first two meetings from Liga MX in 2021 and 2022. The Mexican stars came back with a vengeance when the series restarted in 2024, taking a 4-1 victory in Columbus, Ohio. Order was restored last year in Austin, Texas when the MLS All-Stars won 3-1.

The MLS side will be without Inter Miami stars Messi and Rodrigo De Paul after Argentina lost to Spain in the 2026 World Cup final on July 19. Players who were voted into the MLS side include LAFC's Son Heung-Min, and Hany Mukhtar and goalkeeper Brian Schwake from Nashville SC. The roster also features USMNT players like goalkeeper Matt Freese, defenders Ream and Max Arfsten and midfielder Sebastian Berhalter. Of the 29 players on the MLS roster, 11 played in the 2026 World Cup.

With Messi out, the MLS side's top threat is Petar Musa, as the FC Dallas star shares the league lead in goals with 13, and he also scored one for Croatia at this summer's World Cup. Co-leader Hugo Cuypers will not play Wednesday after Chicago's signing of superstar striker to Robert Lewandowski led to the Fire striker signing to join Liga MX side Monterrey.  

Cincinnati's Evander and Nashville's Sam Surridge both have scored 10 goals, with the latter doing it in just 11 matches. Surridge had a goal in last year's 3-1 MLS victory in Austin. Real Salt Lake's Zavier Gozo, a 19-year-old USMNT prospect, has six goals and five assists in 16 starts in his second season with RSL. 

Son, who represented Korea Republic at the World Cup this month for a third time, shares the MLS lead with nine assists this season and has scored three goals. Anders Dreyer of San Diego also has nine assists, while Evander also has set up eight goals. Longtime Germany star Thomas Muller also will be among the most famous faces on the pitch.

Liga MX's 24-man side will be led by Toluca manager Antonio Mohamed and initially included six Chivas de Guadalajara players, but only two will play. Those set to miss out include former MLS players Brian Gutierrez of Chivas and Brian Rodriguez of Club América. Tijuana teenager Gilberto Mora also was named to the initial team but won't play.

The Liga MX All-Star roster features Cruz Azul captain Erik Lira and Toluca defender Jesus Gallardo, who are among four players who featured in Mexico's World Cup quarterfinal run. Santos Laguna goalkeeper Carlos Acevedo and Club America defender Israel Reyes also were on El Tri's World Cup roster.

Pachuca's Salomon Rondon has scored three goals in the first two matches of Liga MX's Apertura. He is the captain and all-time leading scorer for the Venezuela national team. Rondon had just five goals last year but had 25 over his first two seasons with Los Tuzos. Tigres star Juan Brunetta won MVP honors when Liga MX demolished MLS 4-1 in the 2024 matchup. The 29-year-old has 32 goals and 16 assists over the past three seasons with the Nuevo Leon club.

While the MLS will be missing some key pieces, the Mexican side also has its share of absences after a long summer and with the Apertura just getting started. The Americans should be more settled with their season halfway over. They also should have a big home-field advantage in Charlotte, and they haven't had a lot of trouble with the Liga MX stars previously. The MLS All-Stars should extend their success with a victory.     

Sign up at bet365 and get $150 in bonus bets when you bet $10 or more on the MLS All-Star Game: 

2026 MLS All-Star Game odds

In addition to picking the winner of the match, bettors have other options for wagering on the 2026 MLS All-Star Game. Here are some of the options available at bet365, one of the best betting sites: 

Anytime goalscorers

• Sam Surridge, MLS -150
• Petar Musa, MLS -125
• Evander, MLS -110
• Julian Hall, MLS -105
• Son Heung-Min, MLS -105
• Robert Morales, Liga MX +105
• Hany Mukhtar, MLS +105
• Juan Brunetta, Liga MX +120
• Thomas Muller, MLS +120
• Anders Dreyer, MLS +125
• Kevin Castaneda, Liga  MX +125
• Pep Biel, MLS +125
• Brian Rodriguez, Liga MX +137

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2026 MLS All-Star Game rosters