Lions vs. Chiefs odds, time: Everything you need to crush your 2025 Sunday Night Football picks in NFL Week 6

The Kansas City Chiefs (2-3) and the Detroit Lions (4-1) will clash in a Sunday Night Football showdown in NFL Week 6. Patrick Mahomes and the Chiefs are looking to get back into the win column after a disappointing 31-28 loss to the Jacksonville Jaguars in Week 5. Jared Goff and the Lions are looking to stay hot after winning four straight, holding off the Cincinnati Bengals 37-24 their last time out. 

Kickoff from Arrowhead Stadium is set for 8:20 p.m. ET. Kansas City is a 2.5-point favorite in the latest Lions vs. Chiefs odds, and the over/under for total points scored is 52.5. The Chiefs are -137 favorites on the money line (risk $137 to win $100), while the Lions are +116 underdogs (risk $100 to win $116). Before making any Chiefs vs. Lions picks, make sure you check out the NFL picks from the SportsLine Projection Model.

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The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 41-21 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.    

Now, the model has zoned in on Lions vs. Chiefs. Here are several NFL odds and betting lines for Chiefs vs. Lions:

Here are SportsLine model's best bets for Lions vs. Chiefs:

• Lions +2.5
• Under 52.5 

Lions +2.5

The Lions have covered the spread in 52 of their last 74 games going back to the 2021 season, and they are 4-1-0 ATS in their 2025 campaign. Detroit leads the NFL with 34.8 points per game thanks to the balance between Jared Goff's chemistry with his receiving corps and the rushing duo of Jahmyr Gibbs and David Montgomery. The Lions' last visit to Arrowhead ended in an upset win, and the SportsLine model projects Detroit will cover the spread this time around in 53% of simulations.

Under 52.5

The Kansas City defense is only allowing 190.2 passing yards per game and could be facing a receiving corps that is missing Amon-Ra St. Brown due to a wrist injury. Detroit's defense is also dealing with some injuries, but has held opponents to just 22.4 points per game. The Under is hitting in 55% of simulations, according to the SportsLine projection model. 

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