How to bet on NFL Week 1: Where to bet, best betting sites, apps, promo codes for 49ers vs. Rams in Australia

The NFL is set to play its first game in Australia tonight, featuring an NFC West rivalry between the Los Angeles Rams and San Francisco 49ers. The Rams enter as the preseason favorites to win the 2027 Super Bowl at online sports betting apps after boosting their already star-filled team by trading for reigning NFL Defensive Player of the Year Myles Garrett, who has won the award in two of the last three seasons, and bringing Aaron Donald out of retirement. Rams vs. 49ers marks the second 2026 NFL game of the season, and you can find several online sports betting options below. Bet on the NFL at DraftKings Sportsbook here and get $200 in bonus bets when you bet $5+:

The 49ers vs. Rams is set to kick off at 8:35 p.m. ET in Melbourne, Australia. The latest Rams vs. 49ers odds list the Rams as 3.5-point favorites, with an over/under set at 48.5 points. The 49ers went 12-5 last year despite battling constant injuries, and the Rams and 49ers split their two regular-season meetings. If you're wondering where to find the best NFL odds or looking for sportsbook promos and betting sites for NFL betting, you can read more below. They can help you figure out where to bet on the NFL.

Where to bet on Rams vs. 49ers

DraftKings, FanDuel, bet365 and Hard Rock Bet all have "bet and get" offers for new users. The DraftKings promo code gives new users $200 in bonus bets after a $5 wager. Bonus bets are delivered via eight bonus bets paid out within 21 days, as users will receive two bonus bet tokens every seven days.

The FanDuel promo code involves placing bets for seven straight days to maximize the bonus bet reward. The newest FanDuel promo code gives new users $50 in bonus bets after making a $5 bet each day for your first seven days, resulting in a maximum of $350 in bonus bets. 

The Hard Rock Bet bonus code awards new users $100 in bonus bets, win or lose, after making a $5 bet. These bonus bets are paid out over five weeks as five $20 bonus bet tokens.

The bet365 bonus code is simple. Bet365 gives new users $365 in bonus bets after a first bet of $10 or more, whether the first wager wins or loses.

The BetMGM promo code CBSSPORTS has two offers for new users: up to $1,500 in bonus bets if their qualifying wager loses or $150 in bonus bets if their first wager wins. The offer depends on the state the user resides in.

The Fanatics Sportsbook promo code CBSFAN26 covers a user's first wager of the day for each of their first 10 days. Each bet is covered up to $100 each day for a maximum return of $1,000 in FanCash. Fanatics also offers a secondary, more straightforward option where users can get $350 in FanCash after betting $20. The FanCash is distributed over seven days.

And the Caesars Sportsbook promo code CBSDYW allows new users to double their winnings on 10 bets after signing up and betting $1 or more with their first wager. Caesars awards users 10 profit boost tokens after the first wager settles.

Betting on NFL Week 1

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters the 2026 NFL season on a 53-37 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Rams (-3.5)

The Rams are the clear favorites to win this year's Super Bowl, with odds double the next lowest team in the field. The older team should be at its healthiest for the opener, which could bring the best out of players like Matthew Stafford, Davante Adams and the newly acquired Myles Garrett. The Rams went 12-5 last season, and that's before adding Garrett, arguably the best defensive player in the NFL, this offseason. Stafford won his first NFL MVP last season, leading the league with 4,707 passing yards and 46 touchdowns. Playing at age 37 last season, Stafford proved he has plenty of talent left. The model projects the Rams to cover in 55% of simulations. 

Christian McCaffrey, 49ers, Under 60.5 Total Rushing Yards

"I was a big Christian McCaffrey supporter heading into 2025 and believed he would stay healthy and excel," SportsLine expert Eric Cohen said. "I'm on the other side of the fence this season. After 450 touches last year, I expect the 30-year-old RB to wear down and potentially see reduced workloads early in the season. Last year against the Rams, CMC combined for only 87 yards rushing and did a lot more damage in the passing game. With Los Angeles' defensive line much stronger this year, the 49ers would be smart to throw their running back the ball instead of running him into the line. Either way, I think LA holds McCaffrey to under 50 rushing yards in Australia." Bet on NFL Week 1 with the BetMGM bonus code CBSSPORTS for up to $1,500 in bonus bets:

Deebo Samuel, 49ers, Over 2.5 receptions

"After a one year stopover in DC, Deebo Samuel makes his return to the Bay this season," SportsLine player prop expert Prop Bet Guy Doug said. "He'll enter a 49ers pass-catching corps that's riddled with injuries and question marks heading into Week 1, with George Kittle making his quick return from an Achilles tear, and Mike Evans and Christian McCaffrey both dealing with soft tissue ailments this offseason. Deebo, a low average depth-of-target connoisseur, is likely to move around Kyle Shanahan's offense, giving Brock Purdy quick options. With the Rams sporting one of the better defensive lines the sport has seen, quick options will be en vogue for the 49ers."  Bet on the NFL at DraftKings Sportsbook and get $200 in bonus bets when you bet $5+:

Responsible gaming

Every bettor should practice responsible gaming whenever placing wagers, regardless of your experience level. All the top sportsbooks offer ways to assist bettors, be it gaming limits, activity alerts, live chat options or timeout and self-exclusion measures. Sportsbooks also provide contact information for local and national helplines, including 1-800-MY-RESET, which bettors can call or text 24/7.